Gillespie, WilliamTyagi, NeetuTyagi, Suresh C2011-11-152011-11-152011-04Gillespie William, Tyagi Neetu, Tyagi Suresh C. Role of PPAR, a Nuclear Hormone Receptor in Neuroprotection. Indian Journal of Biochemistry & Biophysics. 2011 Apr; 48(2): 73-81.http://imsear.searo.who.int/handle/123456789/135303Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPAR-alpha is involved in wound healing, stimulation of lipid and folic acid catabolism, inflammation control, inhibition of ureagenesis and peroxisome proliferation. The PPAR/ is involved wound healing, cell proliferation, embryo implantation, adipocyte differentiation, myelination alteration and apoptosis. The PPAR is involved in fat, lipid and calorie utilization, sugar control, inflammation control and macrophage (MQ) matutation. Homocysteine (Hcy) binds to nuclear peroxisome proliferator activated receptor. Increase in PPAR expression decreases the level of nitrotyrosine and increases endothelial nitric oxide concentration, decreases metalloproteinase activity and expression as well as elastinolysis and reverses Hcy-mediated vascular dysfunction. The PPAR initially recognized as a regulator of adipocyte development has become a potential therapeutic target for the treatment of diverse disorders. In addition, the activation of PPAR receptor ameliorates neurodegenerative disease. This review focuses on the recent knowledge of PPAR in neuroprotection and deals with the mechanism of neuroprotection of central nervous system disorder by PPAR.enPPARNeuronal deathIschemiaNeurodegenerative disorderAlzheimer’s diseaseParkinson’s diseaseMultiple SclerosisAnimalsBrain Ischemia --metabolismBrain Ischemia --pathologyBrain Ischemia --therapyCell DeathCentral Nervous System --cytologyCentral Nervous System --metabolismCentral Nervous System --pathologyCytoprotectionHumansNeurodegenerative Diseases --metabolismNeurodegenerative Diseases --pathologyNeurodegenerative Diseases --therapyNeurons --cytologyNeurons --pathologyNeuroprotective Agents --metabolismPPAR gamma --metabolismArticle