Kumar, T RNaidu, M UShobha, J CReddy, D NSubhash, SChaubal, CPrasad, RBabu, S1992-04-012009-05-291992-04-012009-05-291992-04-01Kumar TR, Naidu MU, Shobha JC, Reddy DN, Subhash S, Chaubal C, Prasad R, Babu S. Comparative study of omeprazole and famotidine in the treatment of duodenal ulcer. Indian Journal of Gastroenterology. 1992 Apr; 11(2): 73-5http://imsear.searo.who.int/handle/123456789/65389In a double blind, multicenter, parallel group clinical trial in patients with symptomatic duodenal ulcers, 129 patients were randomized to receive either omeprazole 20 mg once daily (n = 65) or famotidine 40 mg once daily (n = 64) for 2 weeks, and if the ulcers were not healed, for a total of 4 weeks. Seventy four percent of these receiving omeprazole had healed ulcers after 2 weeks compared with 34.3% of those receiving famotidine (p < 0.001). At 4 weeks, the respective figures were 97.3% and 77.6% (p < 0.001). After 2 weeks of treatment, only 11.1% and 29.8% of omeprazole and famotidine treated patients respectively had day time pain (p < 0.02). Diary cards (successfully completed by 2/3rd of patients) showed that omeprazole treated patients required smaller amounts of antacids (p = ns). Over the first two weeks, ulcer healing rate was similar in smokers and non- smokers. No significant side effects were reported in either group. Omeprazole 20 mg/day provides more rapid relief of symptoms and heals a greater proportion of duodenal ulcers at 2 and 4 weeks than famotidine 40 mg/day.engAdolescentAdultAgedDouble-Blind MethodDuodenal Ulcer --drug therapyFamotidine --therapeutic useFemaleHumansMaleMiddle AgedOmeprazole --therapeutic useSmokingClinical Trial