Saini, AshishSingh, MeghnaLal, NandDixit, Jaya2012-08-032012-08-032011-05Saini Ashish, Singh Meghna, Lal Nand, Dixit Jaya. Assessment of combination techniques in enhancing the regenerative potential of tricalcium phosphate graft in treatment of infrabony periodontal defects. Indian Journal of Dental Research. 2011 May-Jun; 22(3): 391-395.http://imsear.searo.who.int/handle/123456789/140031Aims: The purpose of the present study was to evaluate and compare the clinical outcome of infrabony defects following reconstructive surgery with the use of tricalcium phosphate (TCP) alone; TCP and citric acid (CA) root conditioning; and TCP, CA, and oxidized regenerated cellulose (ORC) membrane. Materials and Methods: Thirty-nine systemically healthy subjects with vertical infrabony defect were initially selected based on intraoral periapical radiographs and clinical examination to record probing pocket depth (PPD) and clinical attachment level (CAL). Only 21 defects revealed two-walled configuration on surgical debridement. These defects were selected and randomly allotted to the study groups. Group 1 defects were treated with TCP, group 2 with TCP+CA, and group 3 with TCP+CA+ORC. PPD, CAL, defect depth (DD), and level of alveolar crest (AC) were evaluated at the time of initial surgery and after 6 months at surgical re-entry. These measurements were utilized to calculate PPD reduction, CAL gain, defect fill (DF), %defect fill (%DF), and crestal resorption (CR). Statistical Analysis: A paired t-test was used for assessing changes in each group. Unpaired t-test was used for intergroup comparisons. Results: All three groups showed statistically significant PPD reduction, CAL gain, DF, and %DF, but insignificant CR at the end of 6 months. On intergroup comparison, no statistically significant differences were noted between the groups for all the parameters. Conclusion: Efficacy of combination techniques using TCP+CA; TCP+CA+ORC in treatment of periodontal infrabony defects is at least equal to that of TCP alone.enCitric acidcombination techniquesoxidized regenerated cellulosetricalcium phosphateAdultAlveolar Bone Loss --therapyBiocompatible Materials --therapeutic useBone Regeneration --drug effectsBone Substitutes --therapeutic useCalcium Phosphates --therapeutic useCellulose, Oxidized --therapeutic useCitric Acid --therapeutic useCombined Modality TherapyFollow-Up StudiesGuided Tissue Regeneration, Periodontal --methodsHumansMembranes, ArtificialMiddle AgedOsseointegration --drug effectsPeriodontal IndexTissue Conditioning (Dental) --methodsTreatment OutcomeYoung AdultArticle