Mehra, PranavGarg, MeenakshiKoul, AshwaniBansal, Devi Dayal2013-11-192013-11-192013-10Mehra Pranav, Garg Meenakshi, Koul Ashwani, Bansal Devi Dayal. Effect of (+)-catechin hydrate on oxidative stress induced by high sucrose and high fat diet in male Wistar rats. Indian Journal of Experimental Biology. 2013 Oct; 51(10): 823-827.http://imsear.searo.who.int/handle/123456789/149387Increased lipid peroxidation and reduced glutathione levels in liver of rats fed high sucrose high fat (HSHF) diet were normalized by concomitant administration of (+)-catechin hydrate. Plasma non-enzymatic antioxidants viz. α-tocopherol, ascorbic acid and total thiols decrease were also significantly less in rats administered with (+)-catechin hydrate concomitantly with HSHF diet. Thus the present results indicate that (+)-catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. The study is of clinical importance as oxidative stress is known to be the cause of many clinical manifestations viz. cancer, Parkinson’s disease, atherosclerosis, heart failure, myocardial infarction and many other diseases.enAscorbic acid(+)-Catechin hydrateLipid peroxidationReduced glutathioneThiolsα-TocopherolAnimalsAntioxidants --chemistryAntioxidants --pharmacologyCatechin --analogs & derivativesCatechin --chemistryCatechin --pharmacologyCytoprotection --drug effectsDiet, High-Fat --adverse effectsDietary Sucrose --adverse effectsMaleOxidative Stress --drug effectsRatsRats, WistarWater --chemistryWater --pharmacologyArticle