Ahsan, S M MortazaDas, Bidhan C.Nur, AsaduzzamanZannat, Noor EMahmud, RaselSiddique, Nur AlamSobhan, Sarwar AhmedKhan, Emrul HasanSiddique, Omar2023-07-212023-07-212022-06Ahsan S M Mortaza, Das Bidhan C., Nur Asaduzzaman, Zannat Noor E, Mahmud Rasel, Siddique Nur Alam, Sobhan Sarwar Ahmed, Khan Emrul Hasan, Siddique Omar. Outcome of Longitudinal Pancreatico-Jejunostomy on Pain Control and Pancreatic Function in Chronic Pancreatitis. Annals of International Medical and Dental Research. 2022 Jun; 8(3): 48-542395-28222395-2814http://imsear.searo.who.int/handle/123456789/219975Background: Outcome of drainage operation for chronic pancreatitis are variable. The present study is taken to observe effect of longitudinal pancreatico-jejunostomy (LPJ) on pain control and pancreatic function in chronic pancreatitis in our setting.Material & Methods:Thirty-three patients who underwent LPJ for symptomatic chronic pancreatitis for one year period presented with abdominal pain (100%), steatorrhoea (30.3%), diabetes (66.7%) and weight loss (78.8%). Definitive diagnosis was made on the basis of ultrasonography and MRCP findings. LPJ (Partingtong-Rochelle) operation was done in all patients. Pain (using visual analoge scale), glycemic status (using FBS, 2hABF, HbA1c), body weight, serum zinc levels (as a marker of exocrine function), and serum insulin level (as a marker of endocrine function) were measured immediately after admission and 3 months after operation.Results:Three months after operation pain was completely disappeared in 23 (69.7%) patients, it persisted in different grade in 10 (30.3%) patients and the pain reduction rate was significant. Twenty two patients who had diabetes prior to surgery, their glycemic status significantly decreased and serum insulin level significantly increased (preoperative; 7.1�1 礥/L, postoperative; 14.3�礥/L) in 22 patients with DM after surgery. Serum zinc level increased (preoperative; 80.8�.5 礸/dl, postoperative; 85.3�.7 礸/dl) 3 months after surgery but the difference was not significant (p=0.571). However the body weight of all patients were significantly increased after operation.Conclusions:LPJ reduces abdominal pain and improves both exocrine and endocrine function in patient with chronic pancreatitis. Serum zinc levels can be considered as a tool of exocrine function.Chronic pancreatitisLPJPain controlpancreatic function.Journal ArticleIndiaMedical Officer, Sheikh Russel National Gastroliver Institute and Hospital, Mohakhali, Dhaka, Bangladesh. Email: mortazaahsan@gmail.com, Orcid ID: 0000-0002-2034-9328Professor, Department of Hepatobiliary-Pancreatic and Liver Transplant Surgery, BSMMU, Dhaka, Bangladesh. Email: dbidhan@yahoo.com, Orcid ID: 0000-0003-0956-9095Assistant professor, Department of Hepatobiliary Surgery, Enam medical college Hospital, Savar, Dhaka, Bangladesh. Email: Nahid2532@gmail.com, Orcid ID: 0000-0002-4064-4885Phase B Resident, Department of Paediatric Nephrology, Bangladesh Institute of Child Health, Shyamoli, Dhaka, Bangladesh. Email: drnoorezannat@gmail.com, Orcid ID: 0000-0002-3920-6861Medical officer, Sylhet M. A. G. Osmani Medical College, Sylhet, Bangladesh. Email: Raselmmc36@gmail.com, Orcid ID: 0000-0003-4979-6823Phase B student (HBP-surgery), Department of Hepatobiliary-Pancreatic and Liver Transplant Surgery, BSMMU, Dhaka, Bangladesh. Email: nuralamarif@gmail.com, Orcid ID: 0000-0001-7098-8462Medical Officer, (HBP-surgery), Department of Hepatobiliary-Pancreatic and Liver Transplant Surgery, BSMMU, Dhaka, Bangladesh. Email: rubai.dmc59@gmail.com, Orcid ID: 0000-0001-9040-0136Associate professor, Department of Hepatobiliary and Pancreatic Surgery, Dhaka Medical College and Hospital, Dhaka, Bangladesh. Email: dremrul@gamil.com Orcid ID: 0000-0003-1802-6260.Junior Consultant, Department of Surgery, Keraniganj Upazilla Health Complex, Dhaka, Bangladesh. Email: Omar24th@gmail.com, Orcid ID: 0000-0002-2976-3488.