Puri, S KSharma, PDutta, G P1990-06-012009-06-011990-06-012009-06-011990-06-01Puri SK, Sharma P, Dutta GP. Pattern of relapses in sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys. Journal of Communicable Diseases. 1990 Jun; 22(2): 98-101http://imsear.searo.who.int/handle/123456789/112065The pattern of sequential relapses in 10 rhesus monkeys following inoculation of sporozoites of Plasmodium cynomolgi B has been studied after administering curative dose of chloroquine (5 mg/kg base X 7 days) to eliminate blood parasitaemia after each relapse. Observation for periods ranging from 109 to 245 days showed that the interval between first six relapses was 19.3 +/- 6.77 days (1st relapse), 20.9 +/- 8.43 days (2nd relapse), 22.8 +/- 8.55 days (3rd relapse), 27.8 +/- 10.0 days (4th relapse), 31.67 +/- 11.50 days (5th relapse) and 32.5 +/- 16.26 days (6th relapse). The results of this study indicate a gradual extension of the relapse interval in successive relapses.engAnimalsChloroquine --therapeutic useDisease Models, AnimalMacaca mulattaMalaria --drug therapyRecurrenceTime FactorsJournal Article