Patel, Pinaki BThakkar, Vasudev R2015-06-262015-06-262015-03Patel Pinaki B, Thakkar Vasudev R. Addition of citral controls ROS and reduces toxicity in 5-fluorouracil treated Schizosaccharomyces pombe cells. Indian Journal of Experimental Biology. 2015 Mar; 53(3): 152-157.0975-1009http://imsear.searo.who.int/handle/123456789/158403In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 µg or higher concentration of 5-fluorouracil. The combined treatment was so effective that higher number of cells underwent apoptosis compared to individual treatment of 5-fluorouracil. Citral controlled ROS levels and increased survival of normal cells. Several differentially expressed proteins observed in the citral treatment could further help understanding its mechanism of action.enApoptosisChemotherapyLemongrassPhytomedicineApoptosis --drug effectsDose-Response Relationship, DrugDrug Evaluation, PreclinicalFluorouracil --antagonists & inhibitorsFluorouracil --toxicityFungal Proteins --analysisMonoterpenes --pharmacologyOxidative Stress --drug effectsReactive Oxygen Species --metabolismSchizosaccharomyces --drug effectsSchizosaccharomyces --growth & developmentSchizosaccharomyces --metabolismArticle