Sreekumar, PradeepPisharody, SunilRetnakaran, RajagopalIndani, AshishBhutada, PoonamC., Somanathan2020-04-092020-04-092019-07Sreekumar Pradeep, Pisharody Sunil, Retnakaran Rajagopal, Indani Ashish, Bhutada Poonam, C. Somanathan. Complex coronary intervention outcomes: real world left main coronary artery angioplasty experience from a tertiary care center in South India. International Journal of Advances in Medicine. 2019 Jul; 6(4): 1164-11702349-39252349-3933http://imsear.searo.who.int/handle/123456789/194369Background: Left Main Coronary Artery (LMCA) Disease is among the most complex forms of the coronary artery stenosis, the leading cause of mortality in the world.Methods: In this analysis, 102 patients with elective angioplasty for LMCA stenosis with PCI from 6/2013 to 5/2016, 3 years (70 in GenxSync™ arm and 32 in other devices arm; 100 DES and 2 BMS) were included. RADHIKa Analysis compared post-hoc subgroups of GenxSync™ and control groups.Results: Mean population age was 59.99±12.03 years; 60.27±10.49 years in GenxSync™ arm, and 58.31±14.32 years in control arm. A significant population (44, 43.14%) had diabetes, renal impairment (14, 13.73%) and hypertension (25, 24.51%). The MACCE in GenxSync™ arm was 17 13(18.58%) Versus 5(15.63%) [RR=0.93, RR’=-0.07, ?=-14.01. p=0.3). Most patients presented with unstable Angina (41, 40.20%) in all, 31(44.29%) in GenxSync™ and 10 (31.25%) in Control arm. AWMI and IWMI were 18, 17.65% each, attributed to 12 (17.14%) in GenxSync™ 6 (18.75%) in Control. Effort angina was 15(21.43%) in GenxSync™ and 10 (31.25%) in Control and NSTEMI was 25,24.51% (18 (25.71%)- GenxSync™ 7(21.88%) Control). The MACE in GenxSync™ arm at 24, 12 and 6 months was 12(17.15%), 8(11.43%) and 4(5.71%) respectively versus corresponding MACE in the control arm as 5(15.63%), 2(2.86%) and 2(6.25%) respectively. The TVR was present only in GenxSync™ Arm, which was contributed by 2 CABGs and 12 months and 1 additional PCI at 24 months.Conclusions: In real-world scenario of LMCA cases, performance and safety of various stents were similar. GenxSync™ Sirolimus Eluting Stent, in the post-hoc bifurcation had results similar to other real-world cases, based upon RADHIKa analysis.Complex angioplastyComplex PCIDrug eluting stentGenxSyncleft main angioplastyLeft main coronary artery stenosisLMCA stenosisJournal ArticleIndiaDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, IndiaDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, IndiaDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, IndiaDepartment of Life Sciences Platforms, Tata Consultancy Services Ltd. Mumbai, Maharashtra, IndiaDepartment of Research Methodology, Krishnamugdha Institute of Advanced Learning and Research, Maharashtra, IndiaDepartment of Cardiology, EMS Memorial Co-operative Hospital and Research Center Ltd., Perintalmanna, Kerala, India