Feng, JieXu, YangXu, LiGuan, QiuyueWang, ZhengBai, DingHan, Xianglong2017-01-042017-01-042015Feng Jie, Xu Yang, Xu Li, Guan Qiuyue, Wang Zheng, Bai Ding, Han Xianglong. Integrins and Reorganization of Osteoclast Cytoskeleton under Orthodontic Force. British Journal of Medicine and Medical Research. 2015; 9(10):1-8.2231-0614http://imsear.searo.who.int/handle/123456789/181077Integrins are mechanoreceptors and mediate mechanotransduction by transferring forces into focal adhesions. Osteoclastogenesis starts with adhesion to the bone matrix, leading to cytoskeleton reorganization that is important for osteoclast polarization and migration. However, there are several signaling pathways mediating this process, and integrins have been shown to be important signaling molecules participating osteoclastogenesis. Particularly, integrins have played an important role in both force transduction and osteoclastogenesis. This paper reviewed the findings on the relationship between integrins and reorganization of osteoclast cytoskeleton under orthodontic force.enOrthodontic forceintegrinosteoclastogenesiscytoskeletonArticle