Paudel, Keshab RajDas, Balbhadra PrasadRauniar, G PSangraula, HimalDeo, SatishBhattacharya, S K2009-05-282009-05-282007-06-26Paudel KR, Das BP, Rauniar GP, Sangraula H, Deo S, Bhattacharya SK. Antinociceptive effect of amitriptyline in mice of acute pain models. Indian Journal of Experimental Biology. 2007 Jun; 45(6): 529-31http://imsear.searo.who.int/handle/123456789/60128Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test.engAcute DiseaseAmitriptyline --pharmacologyAnalgesics, Non-Narcotic --pharmacologyAnimalsDisease Models, AnimalDose-Response Relationship, DrugMicePain --drug therapyEvaluation Studies