Chaudhury, AKumar, A G2007-01-232009-05-282007-01-232009-05-282007-01-23Chaudhury A, Kumar AG. In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus. Indian Journal of Medical Microbiology. 2007 Jan; 25(1): 50-2http://imsear.searo.who.int/handle/123456789/53427One hundred and sixty seven isolates of staphylococci isolated from the inpatients of a tertiary care referral hospital in South India were speciated and activity of oxacillin, glycopeptides, linezolid and quinupristin/dalfopristin against these isolates was tested by broth microdilution method. Of the 114 coagulase negative staphylococci (CoNS), 49.1 % were S. haemolyticus, isolated predominantly from urine (64.6%), while the rest belonged to 11 other species. More than half the isolates of S. aureus (52.8%) and 68.4% of the CoNS were oxacillin resistant. All the strains were uniformly susceptible to vancomycin, linezolid and quinupristin/dalfopristin; but 25.6% isolates of S. haemolyticus showed reduced susceptibility to teicoplanin (MIC: 8-16 mg/L). Our study demonstrates the high prevalence of oxacillin resistance among hospital isolates of S. aureus and CoNS in India. Vancomycin, along with the newer agents like linezolid and quinupristin/dalfopristin remains the drug of choice for treating multi drug resistant staphylococcal infections.engAcetamides --pharmacologyAnti-Bacterial Agents --pharmacologyDrug Resistance, Multiple, BacterialIndiaMicrobial Sensitivity TestsOxacillin --pharmacologyOxazolidinones --pharmacologyStaphylococcus --drug effectsStaphylococcus haemolyticus --drug effectsTeicoplanin --pharmacologyVancomycin --pharmacologyVirginiamycin --analogs & derivativesJournal Article