Nso, A PGarcía-Bermejo, CLarru, BMadero, RMuñoz Fernández, M Ade José, M I2012-10-252012-10-252009-11Nso A P, García-Bermejo C, Larru B, Madero R, Muñoz Fernández M A, de José M I. Pathology in children of HIV women. Indian Journal of Pediatrics. 2009 Nov; 76(11): 1125-1130.http://imsear.searo.who.int/handle/123456789/142422Objective. To assess the frequency of perinatal pathology in children exposed to antiretrovirals in perinatal period. Methods. Retrospective observational cohort study. Data collected among uninfected children born to HIV-infected women followed up from 1994 to 2006 in a tertiary Hospital. 220 uninfected children were studied. Factors studied included maternal, obstetrical and pediatric variables. Results. The most common disorder found among children exposed to antiretroviral drugs was anemia (84%); 6,4% of children had neutropenia and more than 24% had thrombocytosis, a finding never described before. Prematurity (24%) and low birth weight (23.6%) rates were high. Several congenital malformations were found: Poland syndrome, angiomas, hypospadias, Pierre-Robin sequence, trisomy 8, craniostosis and others. Long-term follow-up revealed neurological, cardiological and ophthalmological pathologies. Conclusion. Some pathologies are frequent among children exposed to antiretroviral agents during perinatal life. It is crucial to carry out long-term studies to assess the safety of this therapy.enAIDSPregnancyAntiretroviral treatmentAdverse effectsPerinatal pathologyAbnormalities, Multiple --epidemiologyAdultAnemia --chemically inducedAnemia --epidemiologyAnti-Retroviral Agents --therapeutic useChildChild, PreschoolFemaleHIV Infections --drug therapyHIV Infections --epidemiologyHumansIncidenceInfantInfant, NewbornNeutropenia --chemically inducedNeutropenia --epidemiologyPerinatologyPrevalencePuerperal Disorders --epidemiologyPuerperal Disorders --etiologyRetrospective StudiesThrombocytosis --chemically inducedThrombocytosis --epidemiologyArticle