Chandrasekar, BMathur, S KMukherjee, S K2009-05-282009-05-281989-02-01Chandrasekar B, Mathur SK, Mukherjee SK. Anti-secretagogue effect of lithium on isolated rat islets of Langerhans. Indian Journal of Experimental Biology. 1989 Feb; 27(2): 163-5http://imsear.searo.who.int/handle/123456789/63410Administration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.engAnimalsInsulin --biosynthesisIslets of Langerhans --drug effectsLithium --pharmacologyMaleRatsJournal Article