Pandit, RajkishorSingh, RubyRajak, Brijmohan Kumar2024-09-242024-09-242023-06Pandit Rajkishor, Singh Ruby, Rajak Brijmohan Kumar . A Study to Determine the Maternal and Fetal Outcome After Single Loading Dose of Magnesium Sulphate for Eclampsia. International Journal of Medical Research Professionals. 2023 May; 9(3): 17-212454-63562454-6364https://imsear.searo.who.int/handle/123456789/231022Introduction: Eclamptic seizures are a medical emergency and can arise after 20 weeks of gestation, either antepartum, intrapartum, or postpartum. They require urgent intervention to prevent death in the mother and fetus. Magnesium sulphate is the anticonvulsant of choice in prevention and control of eclamptic convulsions. Therefore, the present study was undertaken to determine the maternal and fetal outcome after single loading dose of Magnesium sulphate in comparison to standard Pritchard’s regime for prophylaxis of eclampsia. Materials and Methods: The present cross-sectional hospital based comparative study was conducted among 60 pregnant women with severe pre-eclampsia either in labor or those requiring delivery admitted in the Department of Obstetrics and Gynaecology at Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu. Patients were categorized in two groups - one group A that received only loading dose of magnesium sulphate and other group B that received standard Pritchard's regime of magnesium sulphate. Primary outcome measured were maternal complications, fetal and neonatal outcome that consist of 5 min Apgar score and neonatal admission in baby unit. Data were collected and analysed by SPSS -20 software. Differences between categorical variables were analyzed using chi-square test and p value of <0.05 was considered significant. Results: The fetal outcome in terms of apgar scores 27 at 5 minutes of birth was better in loading dose group i.e., 21 cases (70.0%) versus 15 case (50.0%) in standard regime group but this was statistically not significant as p-value was 0.114. Among 30 cases in each loading dose and standard regime group, there were total 5 neonates (16.7%) in loading dose group and 8 neonates (26.7%) in standard regime got admitted in neonatology and this was statistically not significant as the p- value is 0.347. Conclusion: The results this study showed that the loading dose of magnesium sulphate is comparable to standard Prichard's regime for prophylaxis of eclampsia. This study also concludes that there is statistically no significant difference in maternal and fetal outcome between loading dose group and standard Pritchard's regime group.EclampsiaMagnesium sulphatePrichard's regimeSeizuresJournal ArticleIndiaMBBS, MD (Obs and Gyne), Senior Consultant and Head of Department, Obstetric and Gynecology, MIHS, Provincial Hospital, Janakpur, Madhesh Pradesh, NepalMBBS, MD (Obs and Gyne), Consultant Obstetrician and Gynecologist, MIHS, Provincial Hospital, Janakpur, Madhesh Pradesh, NepalMBBS, MD (Obs and Gyne), Consultant Obstetrician and Gynecologist, MIHS, Provincial Hospital, Janakpur,Madhesh Pradesh, Nepal