Ajayi, O. O.Ajayi, O. B.2023-07-142023-07-142023-05Ajayi O. O., Ajayi O. B.. Short-term Effects of Garlic-Based Diets on mRNA Expression of Angiotensinogen, Angiotensin-1 Converting Enzyme, and Atrial Natriuretic Peptide in Cyclosporine-Induced Prehypertensive Rats. Annual Research & Review in Biology. 2023 May; 38(5): 32-422347-565Xhttp://imsear.searo.who.int/handle/123456789/219413The short-term effects of garlic, Allium sativum L., on the mRNA expression of angiotensin-1 converting enzyme (ACE), angiotensinogen (AGT), and atrial natriuretic peptide (ANP) in cyclosporine-induced prehypertensive rats were investigated in this work. Seven (7) groups of animals totaling n=7 were created. Prehypertensive (induced with 25mg/kg cyclosporine) and normal rats were given 10% and 20% diets based on garlic for 7 days. Alteration of Na+ and K+ levels, increased systolic and diastolic blood pressures, and ACE, AGT & ANP mRNA expressions were all associated with cyclosporin-induced prehypertension. In rats placed on garlic-based diets, these effects were reversed.Hypertensioncyclosporinegarlicrenin-angiotensin system.Journal ArticleIndiaDepartment of Biochemistry, Faculty of Science, Ekiti-State University, Ado-Ekiti, Ekiti-State, Nigeria