Kimura, EAoki, YNakajima, YNiwa, M2009-05-272009-05-271984-03-01Kimura E, Aoki Y, Nakajima Y, Niwa M. Plasma level of diethylcarbamazine in jirds and hamsters. The Southeast Asian Journal of Tropical Medicine and Public Health. 1984 Mar; 15(1): 74-9http://imsear.searo.who.int/handle/123456789/35688The Southeast Asian Journal of Tropical Medicine and Public Health.The relation between the dosage and plasma level of diethylcarbamazine (DEC) in jirds and hamsters was examined by gas-liquid chromatography. When the drug was given intraperitoneally to jirds at 100 mg/kg body weight, the plasma level rose rapidly and reached the maximum level (20-25 micrograms/ml) at 10 minutes and afterwards fell quickly to undetectable level at 4 hours. Even if larger dosage (300 mg/kg) was given, DEC was eliminated completely from the blood circulation within 8 hours. When the same dosages of DEC were given intraperitoneally, the DEC levels remained 2-4 hours longer in the blood of hamsters than in the blood of jirds. DEC given by stomach intubation at 100 mg/kg remained detectable much longer in hamsters (8 hrs) than in jirds (2 hrs). A repeated doses schedule did not show a tendency for the drug to accumulate. DEC was excreted in the urine and feces, but the total amount of drug excreted without metabolic changes was only about 8% of the given dosage. The majority of unmetabolized DEC was excreted in the urine within 0-12 hours.engAdministration, OralAnimalsCricetinaeDiethylcarbamazine --administration & dosageFeces --analysisGerbillinaeInjections, IntraperitonealJournal Article