Thapar, AartiSandhir, RajatKiran, Ravi2009-05-282009-05-282002-08-25Thapar A, Sandhir R, Kiran R. Acephate induced oxidative damage in erythrocytes. Indian Journal of Experimental Biology. 2002 Aug; 40(8): 963-6http://imsear.searo.who.int/handle/123456789/62370The effect of oral administration of acephate (360 mg/kg body weight), for 15 days, daily, was investigated on the erythrocytes of male rats. Activities of acetyl cholinesterase and glucose-6-phosphate dehydrogenase decreased, while those of glutathione-s-transferase and glutathione reductase increased. Decreased glutathione content and increased lipid peroxidation suggest that there was increased oxidative stress in the erythrocytes of treated animals. Increased cholesterol/phospholipid ratio in the erythrocyte membranes and morphological changes in RBCs (scanning electron microscopy studies) were observed in acephate treated animals. The results clearly suggest that acephate induced oxidative stress in erythrocytes leads to morphological changes.engAcetylcholinesterase --metabolismAdministration, OralAnimalsCell Membrane --chemistryCholesterol --metabolismErythrocytes --drug effectsGlucosephosphate Dehydrogenase --metabolismGlutathione --metabolismGlutathione Reductase --metabolismGlutathione Transferase --metabolismInsecticides --toxicityLipid Peroxidation --drug effectsMaleOrganothiophosphorus Compounds --toxicityOxidative Stress --drug effectsPhospholipids --metabolismRatsRats, WistarComparative Study