Hazarika, ASarkar, S N2009-05-282009-05-282001-11-22Hazarika A, Sarkar SN. Subacute toxicity of anilofos, a new organophosphorus herbicide, in male rats: effect on some physical attributes and acetylcholinesterase activity. Indian Journal of Experimental Biology. 2001 Nov; 39(11): 1107-12http://imsear.searo.who.int/handle/123456789/62351In acute toxicity study, rats showed dose-dependent signs of cholinergic hyperactivity and behavioural alterations. Maximum intensity of symptoms was not associated with mortality. Oral LD50 was 1681 mg/kg. In subacute toxicity study, rats were orally administered 50, 100 or 200 mg/kg of anilofos once daily for 28 days. Signs and symptoms were observed mainly with 200mg/kg. At this dose, anilofos induced hypothermia and progressive weight loss. None of the anilofos-treated rats died. Weight of brain, lung, testis was not altered, while of liver, heart, spleen and kidney increased. Anilofos inhibited cholinesterase (ChE) activities of erythrocyte (41-67%), plasma (36%), blood (37-64%), brain (63-73%) and liver (28-48%). Total protein was decreased in plasma and liver. Results indicate moderate toxic potential of anilofos in mammals, substantial contribution of CNS-mediated effects in causing anilofos toxicity and no direct relationship between hypothermia and level of ChE inhibition.engAcetylcholinesterase --bloodAnimalsBrain --drug effectsCholinesterase Inhibitors --toxicityHerbicides --toxicityLethal Dose 50Liver --drug effectsMaleOrgan Size --drug effectsOrganophosphorus Compounds --toxicityRatsRats, WistarJournal Article