Armaini, ArmainiDharma, AbdiSalim, Marniati2020-10-162020-10-162020-05Armaini Armaini, Dharma Abdi, Salim Marniati. The nutraceutical effect of Scenedesmus dimorphus for obesity and nonalcoholic fatty liver disease–linked metabolic syndrome. Journal of Applied Pharmaceutical Science. 2020 May; 2020 May: 070-0762231-3354http://imsear.searo.who.int/handle/123456789/210751Obesity is a major cause of nonalcoholic fatty liver disease (NAFLD), which is identified as a characteristic relatedto metabolic syndrome. This study focuses on the benefits of Scenadesmus dimorphus as a nutraceutical to overcomeNAFLD-linked metabolic syndrome caused by obesity. The research used 30 mice (Mus musculus) divided into sixgroups: normal control, obesity control (OC), and drug control (Orlistat) and S. dimorphus administrated orally for21 days in obese mice with NAFLD-linked metabolic syndrome with doses of 5 mg/20 g body weight (BW), 10mg/20 g BW, and 15 mg/20 g BW. The administration of a high-fat diet can cause obese mice to suffer from NAFLD,resulting in an increase in liver enzymes and changes in lipid metabolism. Administration of S. dimorphus at 15mg/20 g BW decreases the activity of liver enzymes and improves liver function. The statistics test showed significantdifferences (p < 0.05 analysis of variance) to decrease the liver enzyme activity of alanine aminotransferase, aspartateaminotransferase, and alkaline phosphatase compared to OCs. Administration of S. dimorphus resulting in metabolismchanges showed a significant (at p < 0.05) decrease in total cholesterol, triglycerides, and low-density lipoproteincholesterol and increased high-density lipoprotein cholesterol. Microalgae S. dimorphus is beneficial as a nutraceuticalto manage obesity and reverse NAFLD-linked metabolic syndrome in obese mice.ObesityNAFLDmetabolic syndromelipid profileScenedesmus dimorphus.Journal ArticleIndiaDepartment of Chemistry, Biochemistry Laboratory, Faculty of Mathematics and Natural Sciences, Andalas University, Padang 25163, Indonesia.