Chowdhury, T AKhan, MChowdhury, SRashid, MBanu, L PAli, S1998-04-202009-05-271998-04-202009-05-271998-04-20Chowdhury TA, Khan M, Chowdhury S, Rashid M, Banu LP, Ali S. Effect of Norplant on liver function. Bangladesh Medical Research Council Bulletin. 1998 Apr; 24(1): 10-3http://imsear.searo.who.int/handle/123456789/425Bangladesh Medical Research Council Bulletin.Combined pills have known adverse effects on liver function. Progesterone based contraceptives are thought to be safer in this regard. The effect of Norplant, a levonorgestrel contraceptive implant, on liver function was evaluated in 149 Bangladeshi women of reproductive age in this study. Liver function tests and ultrasonography of hepato-biliary system were done before and after the implantation. The patients were followed upto two years. There were non-significant transient rise of serum bilirubin and slight enlargement of liver during the first year. There was no significant change in the levels of AST, ALT, alkaline phosphatase, total protein, albumin-globulin ratio and prothrombin time. The results suggest that Norplant has no adverse effect on liver function.engAdolescentAdultAlanine Transaminase --bloodAlkaline Phosphatase --bloodAspartate Aminotransferases --bloodBile Ducts --drug effectsBilirubin --bloodBlood Proteins --analysisContraceptive Agents, Female --administration & dosageDrug ImplantsEvaluation Studies as TopicFemaleFollow-Up StudiesHumansHypertrophyLevonorgestrel --administration & dosageLiver --drug effectsProgesterone Congeners --administration & dosageProthrombin TimeSerum Albumin --analysisSerum Globulins --analysisJournal Article