Bhatia, MJain, SMaheshwari, M C1994-01-012009-05-301994-01-012009-05-301994-01-01Bhatia M, Jain S, Maheshwari MC. Role of selegiline as initial monotherapy in early Parkinson's disease. Journal of the Association of Physicians of India. 1994 Jan; 42(1): 30-2http://imsear.searo.who.int/handle/123456789/87644Twenty patients of Idiopathic Prakinson's disease in the early phase were enrolled to study the efficacy and safety of selegiline as monotherapy. The mean duration of time before levodopa had to be initiated was 9.75 months. The UPDRS scores for activities of daily living, motor examination, tremor and total score showed significant improvement initially with subsequent worsening. Selegiline was well tolerated and there were no serious side-effects. In conclusion, selegiline may have a short lasting symptomatic effect in IPD and is well tolerated.engActivities of Daily LivingDrug ToleranceFemaleFollow-Up StudiesHumansLevodopa --administration & dosageMaleMiddle AgedMotor Activity --physiologyParkinson Disease --drug therapySafetySelegiline --administration & dosageTime FactorsTremor --physiopathologyJournal Article