Lertsapcharoen, PornthepKhongphatthanayothin, ApichaiChotivittayatarakorn, PairojThisyakorn, ChulePathmanand, ChotimaSueblinvong, Viroj2009-05-272009-05-272005-09-21Lertsapcharoen P, Khongphatthanayothin A, Chotivittayatarakorn P, Thisyakorn C, Pathmanand C, Sueblinvong V. Infective endocarditis in pediatric patients: an eighteen-year experience from King Chulalongkorn Memorial Hospital. Journal of the Medical Association of Thailand. 2005 Sep; 88 Suppl 4(): S12-6http://imsear.searo.who.int/handle/123456789/38246Chotmaihet Thangphaet.OBJECTIVES: To review the clinical features and outcome of the pediatric patients diagnosed with infective endocarditis (IE) at King Chulalongkorn Memorial Hospital over an 18-year period. MATERIAL AND METHOD: From January 1987 to December 2004, 57 pediatric patients; 28 females and 29 males, age ranged from 2 months to 15 years, mean of 8.64 +/- 3.82 years, classified as "definite" IE according to the Duke criteria were reviewed. RESULTS: Of the 57 patients, 42 patients (74%) had underlying congenital heart diseases, 7 patients (12%) had underlying rheumatic heart disease, 8 patients (14%) had previously normal heart. Nine patients had history of previously palliative or corrective surgery. Blood cultures were positive in 26 patients (46%). Streptococci and staphylococci were the most commonly isolated organisms. Two-dimensional echocardiography demonstrated vegetations in 56 patients (98%). The location of the vegetations was in the right heart in 30 patients (54%) and in the left heart in 26 patients (46%). Complications occurred in 28 patients (49%). Common complications included congestive heart failure, cerebral emboli, septic shock, and mycotic aneurysm. The overall mortality was 11% (6 patients). By statistical analysis, vegetations in the left heart had a higher incidence of complication than that in the right heart. The vegetation size of > or =10 mm had a significant higher incidence of embolic events. CONCLUSION: The clinical features and outcomes of the present study have a similar pattern as the earlier studies. The rates of complications and mortality are still high.engAdolescentChildChild, PreschoolEmbolization, TherapeuticEndocarditis, Bacterial --complicationsFemaleHeart Defects, Congenital --complicationsHeart Failure --etiologyHospitalization --statistics & numerical dataHospitals, Urban --utilizationHumansInfantMaleMedical AuditOutcome Assessment (Health Care)Retrospective StudiesRisk FactorsStaphylococcus aureus --isolation & purificationStreptococcus --isolation & purificationThailandTime FactorsJournal Article