Chatterjee, Pranab KrBairagi, DebasisRoy, SudiptaMajumder, Nilay KrPaul, Ratish ChBagchi, Sunil Ch2005-07-222009-05-312005-07-222009-05-312005-07-22Chatterjee PK, Bairagi D, Roy S, Majumder NK, Paul RCh, Bagchi SCh. Comparative randomised active drug controlled clinical trial of a herbal eye drop in computer vision syndrome. Journal of the Indian Medical Association. 2005 Jul; 103(7): 397-8http://imsear.searo.who.int/handle/123456789/103691A comparative double-blind placebo-controlled clinical trial of a herbal eye drop (itone) was conducted to find out its efficacy and safety in 120 patients with computer vision syndrome. Patients using computers for more than 3 hours continuously per day having symptoms of watering, redness, asthenia, irritation, foreign body sensation and signs of conjunctival hyperaemia, corneal filaments and mucus were studied. One hundred and twenty patients were randomly given either placebo, tears substitute (tears plus) or itone in identical vials with specific code number and were instructed to put one drop four times daily for 6 weeks. Subjective and objective assessments were done at bi-weekly intervals. In computer vision syndrome both subjective and objective improvements were noticed with itone drops. Itone drop was found significantly better than placebo (p<0.01) and almost identical results were observed with tears plus (difference was not statistically significant). Itone is considered to be a useful drug in computer vision syndrome.engAdultAnalysis of VarianceComputersDouble-Blind MethodFemaleHumansMaleOphthalmic Solutions --therapeutic usePlant Preparations --therapeutic useStatistics, NonparametricTreatment OutcomeVision Disorders --drug therapyComparative Study