Samarth, R MSaini, M RMaharwal, JDhaka, AKumar, Ashok2009-05-282009-05-282002-11-19Samarth RM, Saini MR, Maharwal J, Dhaka A, Kumar A. Mentha piperita (Linn) leaf extract provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice. Indian Journal of Experimental Biology. 2002 Nov; 40(11): 1245-9http://imsear.searo.who.int/handle/123456789/59115Intestinal protection in mice against radiation injury by M. piperita (1 g/kg body weight/day) was studied from day 1 to day 20 after whole body gamma irradiation (8 Gy). Villus height, goblet cells/villus section, total cells, mitotic cells and dead cells/crypt section in the jejunum are good parameters for the assessment of radiation damage. There was significant decrease in the villus height, number of total cells and mitotic cells/crypt section, whereas goblet cells and dead cells showed significant increase after irradiation. Mentha pretreatment resulted in a significant increase in villus height, total cells and mitotic cells, whereas goblet cells and dead cells showed a significant decrease from respective irradiated controls at each autopsy day. The results suggest that Mentha pretreatment provides protection against radiation induced alterations in intestinal mucosa of Swiss albino mice.engAnimalsCobalt RadioisotopesDose-Response Relationship, DrugDose-Response Relationship, RadiationGamma RaysIntestinal Mucosa --pathologyMaleMentha piperitaMicePhytotherapyPlant Extracts --therapeutic usePlant LeavesRadiation Injuries, Experimental --etiologyRadiation-Protective Agents --therapeutic useWhole-Body IrradiationComparative Study