Sharma, PPillai, C RDevi Sharma, J2009-05-282009-05-282000-11-09Sharma P, Pillai CR, Devi Sharma J. In vitro schizontocidal activity of standard antimalarial drugs on chloroquine-sensitive and chloroquine-resistant isolates of Plasmodium falciparum. Indian Journal of Experimental Biology. 2000 Nov; 38(11): 1129-33http://imsear.searo.who.int/handle/123456789/61713The expanding foci of multiple drug resistant malaria and emergence of different strains requires the reassessment of antimalarial activity with various drugs. In vitro response of a chloroquine sensitive and a chloroquine resistant isolate of P. falciparum to a group of 6 quinine derived and 3 artemisinin derived standard drugs has been screened, to evaluate schizontocidal activity of the drugs. In a conventional test system the IC50s were derived from the log dose response curves and evaluated by a rigorous statistical interpretation. Analysis by Tukey's test was significant for the quinine related drugs (Q < or = 0.01) and excludes the statistical significance of artemisinin related drugs in these isolates. The dose-responses of these two isolates vary with quinine derivatives, with some overlap at lower doses for the sensitive isolate than for the resistant one which manifests at higher doses.engAnimalsAntimalarials --pharmacologyChloroquine --pharmacologyDrug ResistancePlasmodium falciparum --drug effectsIn Vitro