Majumdar, SParameswarrao, PSankar, MO, Smyrna.2023-07-142023-07-142022-12Majumdar S, Parameswarrao P, Sankar M, O Smyrna.. Solitary Plasmacytoma of Mandible – A Rare Dyscrasia- Case Report and Review of Literature. Oral and Maxillofacial Pathology Journal. 2022 Dec; 13(2): 168-1702322-03840976-1225http://imsear.searo.who.int/handle/123456789/218489Introduction: The plasma cell neoplasms may present in soft tissue as extramedullary plasmacytomas, bone as a solitary plas- macytoma of bone, or as part of the multifocal disseminated disease multiple myeloma. Aim of study: The study aims to report solitary plasmacytoma in the gnatic bone oral cavity, which is also mimicking as malig- nant neoplasm of bone, seen in a female patient. Case Report: A 38-year-old female patient reported to the outpatient department of our hospital complaining of pain and swelling over the left lower one-third region of the face for one month CBCT analysis shows a hypodense area involving 35 regions extending towards ascending rami of the mandible. Conclusion: Plasmacytoma, despite being a lesion with slow, asymptomatic growth, can assume large volumes, making proper treatment difficult. When there is no bone involvement and it is diagnosed early, the success of treatment is generally higher. The treatment of choice is radiotherapy, with good results for the remission of the lesionPlasma cell neoplasmsMultiple myelomaSolitary PlasmacytomaJournal ArticleIndiaDept of Oral Pathology & Microbiology, GITAM Dental College & Hospital, Visakhapatnam