Misra, RHissaria, PTandon, ViniAggarwal, AmitaKrishnani, NDabadghao, S2003-09-092009-05-302003-09-092009-05-302003-09-09Misra R, Hissaria P, Tandon V, Aggarwal A, Krishnani N, Dabadghao S. Primary Sjogren's syndrome: rarity in India. Journal of the Association of Physicians of India. 2003 Sep; 51(): 859-62http://imsear.searo.who.int/handle/123456789/85751OBJECTIVE: Primary Sjogren's syndrome (SS) is rarely reported from India. We have studied the clinical spectrum and immunological profile of patients with primary SS. METHODS: A prospective analysis of patients with primary Sjogren's syndrome fulfilling San Francisco criteria, seen at our clinic in the last 10 years was carried out. RESULTS: The study included 26 patients, 21 being women. The presenting symptoms included dry eyes, dry mouth, and arthritis/arthralgia. Extra-glandular manifestations were glomerulonephritis, vasculitis, renal tubular acidosis and peripheral neuropathy. The important laboratory abnormalities were hypergammaglobulinaemia (16/20), antinuclear antibodies (18/26), anti-La (11/19) and anti-Ro (10/19). Minor salivary gland provided a definitive diagnosis in 16/26 (60%). CONCLUSION: The prevalence of primary Sjogren's syndrome is rare even in tertiary care rheumatology clinics. The clinical and immunological profile as seen here is similar to that reported in Western countries.engAdultFemaleHumansIndia --epidemiologyMaleMiddle AgedPrevalenceProspective StudiesSjogren's Syndrome --diagnosisJournal Article