Putra, Agus Dody Pranata SuadiSuryana, KetutWulandari, Dewi CaturPriyadarshini, Ida Ayu Uttari2023-08-282023-08-282022-08Putra Agus Dody Pranata Suadi, Suryana Ketut, Wulandari Dewi Catur, Priyadarshini Ida Ayu Uttari. Stevens-Johnson syndrome induced by carbamazepine andamitriptyline in diabetic patient: a case report. International Journal of Advances in Medicine. 2022 Aug; 9(8): 875-8782349-39332349-3925http://imsear.searo.who.int/handle/123456789/225862Stevens-Johnson syndrome (SJS) is systemic immune reactions (type IV hypersensitivity) that are usually present by blistering and erosions of skin and mucous membranes with involvement of multiple organ systems. The incidence of SJS is rare, with the common comorbidities are diabetes mellitus, epilepsy, hypertension, and stroke. This condition is associated with systemic proinflammatory state. Diabetes mellitus is a metabolic disorder that is characterized by abnormally elevated levels of blood glucose due to glucose intolerance, hyperglycemia, and impaired insulin secretion. Nowadays, pathogenesis of diabetes is considered to be dysregulation of immune factors that are recognized as important etiological components in the development of insulin resistance. We report a case of a 30-years-old man with fever and sore throat, who had type 2 diabetes mellitus (T2DM) and used carbamazepine and amitriptyline for diabetic neuropathy, then followed by redness and blistering on his lips, palates, face, and trunk which subsequently diagnosed with SJS.Steven-Johnson syndromeDiabetes mellitusImmune reactionsJournal ArticleIndiaDepartment of Internal Medicine, WangayaRegional Hospital, Denpasar, Bali, Indonesia