Joseph, A.Rajan, C.Kharlynnai, D.P. V., V.2024-09-242024-09-242024-08Joseph A., Rajan C., Kharlynnai D., P. V. V.. A study on pharmacist intervention in anti-epileptic drugs at a tertiary care hospital. International Journal of Research in Medical Sciences. 2024 Aug; 12(8): 2892-28982320-60712320-6012https://imsear.searo.who.int/handle/123456789/234151Background: Antiepileptic drugs (AEDs) have been used for the treatment of epilepsy and other neurological disorders since 19th century. Several classes of AEDs are available for epilepsy, many of them are also used for migraines, bipolar disorder, schizophrenia, depression, and neuropathy. Methods: Total 212 patients participated in an Ambi-directional observational cohort study conducted at Mallige medical center, Bangalore. Reviewed and evaluated both inpatients and outpatients case sheets and the data were entered into Microsoft excel. The data was analysed using version 27 of SPSS and statistical significance was determined by using p value less than 0.05 and Pearson correlation. Results: The result show that among 212 patients 130 were males and 82 females and the major risk factors were hypertension and type 2 diabetes mellitus. Levetiracetam and pregabalin were the commonest AED prescribed. Among 109 adverse drug reaction (ADRs) occurred in 82 patients, dizziness, and sedation (20%) were common. Valproate (17.4%) was the main drug causing ADRs and treatment was discontinued in 2 patients due to phenytoin (PHT) toxicity. A total of 90 drug-drug interaction (DDI) was observed using online drug database. Conclusions: This study revealed that monitoring and evaluating the prescription pattern in these patients enables modification in prescribing pattern that improves the patientæ¯ quality of life and can reduce drug related problems. Clinical pharmacist plays an important role in evaluating the prescribing pattern of drugs based on standard treatment guidelines and rationality of prescriptions.EpilepsyAEDsRisk factor analysisADRsDrug-interactionPrescribing patternsA study on pharmacist intervention in anti-epileptic drugs at a tertiary care hospitalJournal ArticleIndiaDepartment of Pharmacy Practice, Mallige College of Pharmacy, Siluvepura, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, Mallige College of Pharmacy, Siluvepura, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, Mallige College of Pharmacy, Siluvepura, Bangalore, Karnataka, IndiaDepartment of Pharmacy Practice, Mallige College of Pharmacy, Siluvepura, Bangalore, Karnataka, India