Pahari, D KDas, SDutta, B NBanerjee, D1993-06-012009-05-311993-06-012009-05-311993-06-01Pahari DK, Das S, Dutta BN, Banerjee D. Prognosis and management of membraneous nephropathy. Journal of the Association of Physicians of India. 1993 Jun; 41(6): 350-1http://imsear.searo.who.int/handle/123456789/95307Patients of idiopathic membranous nephropathy (MGN) were randomly assigned to received steroid and cyclophosphamide every other month (Gr-I) and steroid alone (Gr-II). Of 36 patients in Gr.I, 33 patients achieved complete remissions, 2 had relapsing course with remission on further courses of therapy and only one has reached end stage renal failure. In contrast, of the 35 patients in Gr. II, 15 (P < 0.001) achieved complete remission, 7 are in partial remission, 5 have no response, another 5 have deterioration of renal function of which two required dialysis, and 3 have relapsing course after the initial remission. Mean follow up period was 46 +/- 10.2 months. We conclude that steroid and cyclophosphamide every other month is highly effective in achieving remission in patients with membranous nephropathy.engAdolescentAdultAgedCyclophosphamide --administration & dosageDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesGlomerulonephritis, Membranous --drug therapyHumansMaleMiddle AgedPrednisolone --administration & dosagePrognosisClinical Trial