Lokeshwar, M RSinghal, TUdani, S VKapadia, F N2006-06-062009-05-272006-06-062009-05-272006-06-06Lokeshwar MR, Singhal T, Udani SV, Kapadia FN. Treatment of acute infectious purpura fulminans with activated protein C. Indian Pediatrics. 2006 Jun; 43(6): 535-8http://imsear.searo.who.int/handle/123456789/8826Infectious purpura fulminans is associated with high mortality and morbidity despite standard antimicrobial therapy. We report satisfactory clinical outcome in two children with sepsis associated purpura fulminans who were treated with activated protein C (APC). There is need for proper evaluation of the efficacy of this extremely expensive therapeutic modality by randomized controlled trials before it is made standard of care in childhood infectious purpura fulminans.engAcute DiseaseAnticoagulants --therapeutic useBlood Coagulation Factors --drug effectsChild, PreschoolHumansInfantMaleProtein C --therapeutic usePurpura, Schoenlein-Henoch --drug therapyReceptors, Cell Surface --drug effectsTreatment OutcomeCase Reports