Sharma, JDey, PSaha, ANaoshram, NDutta, M.2025-05-142025-05-142024-12Sharma J, Dey P, Saha A, Naoshram N, Dutta M.. Hypothalamo-pituitary-adrenal axis dysfunction presenting as a life threatening acute medical emergency: A case study. The Southeast Asian Journal of Case Report and Reviews. 2024 Dec; 11(4): 122-1252319-1090https://imsear.searo.who.int/handle/123456789/247923Hypothalamo-pituitary-adrenal axis dysfunction can present clinically as one of the few endocrinological emergencies found in daily clinical practice. The HPA axis primarily deals with stress response, energy metabolism, immune function and neuropsychiatric function. Unfortunately the clinical presentation of HPA axis dysfunction is non-specific and often progresses insidiously resulting in late diagnosis, or in severe cases present with acute circulatory collapse. Here we present a case where a 60 year-old lady who presented with shock, altered mental status, bradycardia and hypoglycemia, was found to have HPA axis dysfunction and was managed effectively with glucocorticoids along with other supportive management.HypoglycemiaNeuropsychiatricHypothalamo-pituitary-adrenalJournal ArticleIndiaDept. of Medicine and Rheumatology, Apollo Multispeciality Hospital, Kolkata, West Bengal, IndiaDept. of Medicine and Rheumatology, Apollo Multispeciality Hospital, Kolkata, West Bengal, IndiaDept. of Medicine and Rheumatology, Apollo Multispeciality Hospital, Kolkata, West Bengal, IndiaDept. of Medicine and Rheumatology, Apollo Multispeciality Hospital, Kolkata, West Bengal, IndiaDept. of Medicine and Rheumatology, Apollo Multispeciality Hospital, Kolkata, West Bengal, India