Kansal, D KChakrabarti, A2001-07-082009-06-012001-07-082009-06-012001-07-08Kansal DK, Chakrabarti A. Neurobehavioural study of subchronic administration of oxydemeton-methyl (insecticide and acaricide) in rats. Indian Journal of Physiology and Pharmacology. 2001 Jul; 45(3): 329-36http://imsear.searo.who.int/handle/123456789/106897Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium induced hypnosis in rats after intermittent aerosol spray inhalational exposure, for 1/2 hour daily for 7 consecutive days, compared to the saline control group. Further, ED50 +/- SEM value for haloperidol induced catalepsy, CD50 +/- SEM value for pentylenetetrazole induced seizure and CI50 +/- SEM value for electroshock (i.e. the dose of haloperidol, PTZ and intensity of electroshock producing catalepsy or positive seizure response in 50% of rats) were significantly decreased after 7 days exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect, extrapyramidal effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.engAnimalsAntipsychotic Agents --toxicityBarbital --pharmacologyBehavior, Animal --drug effectsCatalepsy --chemically inducedConvulsantsElectroshockExploratory Behavior --drug effectsFemaleHaloperidol --toxicityHypnotics and Sedatives --pharmacologyInsecticides --toxicityMaleNervous System --drug effectsOrganothiophosphorus Compounds --toxicityPentylenetetrazoleRatsRats, Sprague-DawleySeizures --chemically inducedSleep --drug effectsTime FactorsJournal Article