Pradeep, P VTiwari, PMishra, AAgarwal, GAgarwal, AVerma, A KMishra, S K2008-04-162009-06-022008-04-162009-06-022008-04-16Pradeep PV, Tiwari P, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK. Pulmonary function profile in patients with benign goiters without symptoms of respiratory compromise and the early effect of thyroidectomy. Journal of Postgraduate Medicine. 2008 Apr-Jun; 54(2): 98-101http://imsear.searo.who.int/handle/123456789/117636BACKGROUND: A large number of patients in our country develop goiters which seem to be apparently asymptomatic. Conventional radiography does not address the abnormal air flow dynamics. Flow volume loop studies have shown characteristic dampening of both inspiratory and expiratory curves. Pulmonary function tests (PFT) can provide a simple noninvasive method of assessing airway compromise. AIM: To address the effect of longstanding asymptomatic, benign goiter by performing PFT on the preoperative airway dynamics and the early postoperative changes at six weeks. SETTING AND DESIGN: Tertiary care center, Prospective study. MATERIALS AND METHODS: Sixty-four patients with benign goiters were included after they satisfied the necessary exclusion and inclusion criteria. Pulmonary function tests were performed in the pre and postoperative period. STATISTICAL ANALYSIS USED: SPSS ver. 10 software, Pearson's Bivariate correlation and students T test. Results: The preoperative PFT showed significant reduction in the Vital capacity (VC), Forced Vital Capacity (FVC), Forced expiratory volume in one second (FEV1), mid expiratory flow (MEF 25) and MEF 50 in the females and VC, FVC and FEV1 in males. Postoperatively significant improvement was observed in the tidal volume (VT) and FEV1 in the females and airway resistance in males. CONCLUSIONS: Pulmonary function tests can demonstrate the unmanifested abnormal airflow dynamics in benign asymptomatic goiters, which would have otherwise taken years to manifest. This abnormality improved after thyroidectomy, especially the forced expiratory maneuvers. The duration and weight of the goiter correlated well with reduction in FEV1 and its subsequent improvement after surgery in females.engAdolescentAdultFemaleGoiter --complicationsHumansLung --physiopathologyMaleMiddle AgedPostoperative Complications --diagnosisPostoperative PeriodPredictive Value of TestsPreoperative CareProspective StudiesRespiratory Function TestsThyroidectomyTreatment OutcomeYoung AdultJournal Article