Bun Navy, KPrem Prey, SLynen, LSovanna, PBell, J DHarwell, J I2009-05-272009-05-272005-09-28Bun Navy K, Prem Prey S, Lynen L, Sovanna P, Bell JD, Harwell JI. The first reported cases of disseminated histoplasmosis in Cambodia, complicated by multiple opportunistic infections. The Southeast Asian Journal of Tropical Medicine and Public Health. 2005 Sep; 36(5): 1272-4http://imsear.searo.who.int/handle/123456789/31008The Southeast Asian Journal of Tropical Medicine and Public Health.Although disseminated histoplasmosis is recognized as a common opportunistic infection in HIV-infected persons living in endemic areas, it is not widely reported in Southeast Asia, and has not been reported in Cambodia. It remains unanswered whether this is secondary to a low disease prevalence, or whether the disease, which is associated with a nonspecific clinical presentation, is under diagnosed. In addition to a review of the literature regarding histoplasmosis in Southeast Asia, we provide a description of two HIV-1 infected patients with documented disseminated histoplasmosis complicating other opportunistic infections in Phnom Penh, Cambodia. These two cases highlight the need for both a high clinical suspicion, and reliable laboratory testing, in a setting where there is likely to be more than one infection complicating the patient's clinical course.engAIDS-Related Opportunistic Infections --complicationsAdultAmphotericin B --therapeutic useAntifungal Agents --therapeutic useCambodia --epidemiologyFemaleFluconazole --therapeutic useHistoplasmosis --complicationsHumansMaleCase Reports