Gulati, SheffaliSalhotra, AmandeepSharma, M CSarkar, ChitraKalra, Veena2004-11-022009-05-302004-11-022009-05-302004-11-02Gulati S, Salhotra A, Sharma MC, Sarkar C, Kalra V. Central core disease. Indian Journal of Pediatrics. 2004 Nov; 71(11): 1021-4http://imsear.searo.who.int/handle/123456789/83211Central core disease is a congenital myopathy characterized by generalized hypotonia, muscle weakness and presence of central cores on muscle biopsy. It generally presents during infancy. It is familial with autosomal dominant inheritance [Chromosome 19q13.1; Gene Locus RyR1 (Ryanodine receptor gene)]. We report here two cases of central core disease in a 3-year-old male child and 8 year old female child.engActivities of Daily LivingBiopsy, NeedleChildChild, PreschoolExercise TherapyFemaleHumansImmunohistochemistryIndiaMaleMyopathy, Central Core --diagnosisPrognosisRare DiseasesRisk AssessmentSeverity of Illness IndexCase Reports