Khabour, Omar FAl-azzam, Akram MAlfaouri, Almuthana AZayed, FaheemSadiq, May F2015-08-312015-08-312013-01Khabour Omar F, Al-azzam Akram M, Alfaouri Almuthana A, Zayed Faheem, Sadiq May F. Association of Polymorphisms in DAZL Gene with Male Infertility. British Journal of Medicine and Medical Research. 2013 Jan-Mar; 3(1): 41-48.http://imsear.searo.who.int/handle/123456789/162783Objectives: To investigate the association between A260G (Thr12Ala) and A386G (Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene (DAZL) and infertility in Jordanian males. Methods: Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile subjects were recruited in the study. DAZL SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Results: The data showed that the A260G SNP is common in the Jordanian population with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in the studied population. No significant association was found between the examined SNPs in DAZL gene and men infertility. Conclusion: The A260G and A386G polymorphisms of DAZL seem to play no role in men infertility in Jordanian population.enDeleted in azoospermia-like genesingle nucleotide polymorphismJordaninfertilitymaleArticle