Aldahlawi, Salwa2020-09-242020-09-242019-01Aldahlawi Salwa. Evaluation of Serum RANKL and OPG Concentrations in Patients with Periodontitis in Saudi Arabia. International Journal of Medical Research Professionals. 2019 Jan; 8(1): 45-512277-3657http://imsear.searo.who.int/handle/123456789/203642Objective: To investigate RANKL and OPG serum concentrations and the RANKL/OPG ratio in patients diagnosed withchronic periodontitis and attending dental school clinics in Makkah, Saudi Arabia. Methods : Patients seeking dentaltreatment at the Faculty of Dentistry Clinic, Umm Al Qura University were divided into periodontitis and control groupsbased on their clinical findings. Periodontitis was diagnosed in patients with a PD >4mm or CAL >3mm at more than 30%of the examined sites, and the radiographic evidence of alveolar bone loss was > 30% of teeth. RANKL and OPG serumconcentrations (pg/ml) and RANKL/OPG ratio were determined. Results: Forty-three patients, including 32 females and 11males with a mean age of 30 +/_ 8.48, were studied. Thirty patients were diagnosed with periodontitis, and 13 were in thecontrol group. The patients with periodontitis had significantly higher RANKL (31.8 +/_ 27.5 vs. 18.7 +/_ 14.2 pg/ml,p=0.04) and OPG concentrations (58.0 +/_ 23.2 vs. 45.3 +/_ 10.0 pg/ml, p=0.03) than the control patients. The patients withperiodontitis that smoked had significantly lower serum RANKL concentrations than those that did not smoke (37.8 +/_ 10.0vs. 14.8 +/_ 10.0, p=0.0057 pg/ml). The RANKL/OPG serum ratio was higher in non-smokers than in smokers (0.6 vs. 0.3,p=0.017). The patients with generalized advanced periodontitis had significantly higher serum RANKL concentrations thanthose with the localized disease (56.8 +/_ 42.0 vs. 22.0 +/_ 12.8 pg/ml, p=0.03). Serum RANKL/OPG ratio was increased inpatients with generalized disease (0.96 vs. 0.39, p=0.036). Serum RANKL/OPG ratio was also correlated with the amount ofCAL (r = 0.459, p=0.04). Conclusions: Serum RANKL concentrations were increased in patients with periodontitis, in nonsmokers, and in patients with the generalized advanced disease.Periodontal DiseaseSerumRANKLOPGBiomarkerAlveolar Bone LossJournal ArticleIndiaAssistant Professor, Department of Basic and Clinical Oral Sciences, Division of Periodontology, College of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia.