Priyanka, R KKazi, Farah NaazSharma, J V PranavGhosh, Shaurav2023-08-092023-08-092022-09Priyanka R K, Kazi Farah Naaz, Sharma J V Pranav, Ghosh Shaurav. A giant parathyroid adenoma mimicking a thyroid swelling: A case report. Indian Journal of Case Reports. 2022 Sep; 8(9): 285-2872454-13032454-129Xhttp://imsear.searo.who.int/handle/123456789/222231Giant parathyroid adenomas are uncommon. Its clinical management is challenging. Our study抯 goal is to share our experience with pre-operative localization of parathyroid adenomas while emphasizing the importance of intraoperative parathyroid hormone (IOPTH) assays in such situations. Here, we present the case of a 46-year-old woman who was diagnosed with parathyroid adenoma. The clinical aspects, pre-operative management, and surgical procedure have all been examined. Parathyroid hormone levels were reduced by 90% following surgical removal of the tumor and an IOPTH assay. IOPTH significantly improves surgical success rates in patients with only one positive imaging test result and adds significant value to surgical decision-making.Giant parathyroid adenomaHypercalcemiaIntraoperative parathyroid hormone assayParathyroid adenomaThyroid swellingJournal ArticleIndiaSenior ResidentResidentAssistant Professor, Department of General Surgery, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India