Dholakia, Sandip P.Kanada, Kaushik B.Parmar, Ghanshyam R.2020-10-162020-10-162020-06Dholakia Sandip P., Kanada Kaushik B., Parmar Ghanshyam R.. Synthesis and biological evaluation of novel substituted pyrrolo[2,3-d]pyrimidines as anticancer agents. Journal of Applied Pharmaceutical Science. 2020 Jun; 2020 Jun: 006-0112231-3354http://imsear.searo.who.int/handle/123456789/210763Pyrrolopyrimidines are well known scaffold, which play a critical role as anticancer agents, so it thought of interest tosynthesize a series of novel substituted pyrrolo[2,3-d]pyrimidines having diverse groups at position C4 and N7 of thepyrrolo[2,3-d]pyrimidine core and performed in vitro screening against MDA-MB-468 (breast cancer cell line) cellline. The details of the synthetic methods and characterization data of the synthesized compounds have been presentedin this study. Compounds 8a, 8h, 8j, 9h, 9i, 9j, 9m, 9n, and 9o showed the excellent anticancer activity compared tostandard doxorubicin with an IC50 value of 6.17 µM/ml against MDA-MB-468 (breast cancer cell line), which wasnon-toxic to normal vero cell line.Doxorubicinpyrrolo[2,3-d] pyrimidineanticancerbreast cancerJournal ArticleIndiaDepartment of Chemistry, Shankersinh Vaghela Bapu Institute of Pharmacy, Gandhinagar, Gujarat, India.Department of Chemistry, Saraswati Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India.Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.