Kumar, Dr. RajAdhikari, Dr. Indra Prasad2023-07-212023-07-212023-07Kumar Dr. Raj, Adhikari Dr. Indra Prasad. ROLE AND USEFULNESS OF BIOCHEMICAL MARKERS IN COVID-19 CASES: A SYSTEMATIC REVIEWS. Global Journal For Research Analysis . 2023 Jul; 12(7): 1-42277-8160http://imsear.searo.who.int/handle/123456789/220784Background: Coronavirus disease 2019 (COVID-19) is a highly contagious viral illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has a catastrophic effect on the world resulting in more than 25 million deaths worldwide. In India on 30th January 2020 rst positive case in a student from Kerala of the SARS-CoV-2 infection. The SARS-CoV-2 can cause serious clinical complications, especially in elderly patients and in those with co-morbidities, especially diabetes obesity; cancer and digestive, endocrine, nervous and respiratory systems pathologies. The elevated biomarkers level was noticed in severe COVID 19 cases compared to non-covid 19 patients, revealing that D-dimer, CRP, ferritin, LDH, are signicantly correlated to COVID-19 severity. This review study aims to identify the most effective biomarker among C- reactive protein, IF6, D-dimer and ferritin to predict disease severity. This review intends to outline the biochemical laboratory tests that are useful in disease monitoring and assessment of severity in conrmed cases of COVID-19.Journal ArticleIndiaProfessor Department of Biochemistry BRD Medical College Gorakhpur. *Corresponding AuthorDemonstrators Department of Biochemistry BRD Medical College Gorakhpur.