Teeraratkul, AcharaDangsuwan, TassalapaWittitsuwannakul, RapeepunKerdsomnuk, SirikulSawaengsakdi, LawanRoengrak, SiriratWititsuwannakul, DhirayosVichyanond, Pakit2012-04-172012-04-171997-09Teeraratkul Achara, Dangsuwan Tassalapa, Wittitsuwannakul Rapeepun, Kerdsomnuk Sirikul, Sawaengsakdi Lawan, Roengrak Sirirat, Wititsuwannakul Dhirayos, Vichyanond Pakit. Epidemiology of latex allergy among healthcare personnel at Siriraj Hospital. Siriraj Medical Journal, 1997 Sept; 49(9): 837-845.http://imsear.searo.who.int/handle/123456789/137720AIIergic reactions to latex allergens, ranging from contact dermatitis, urticaria, angioedema, rhinoconjunctivitis, asthma and life-threatening anaphylaxis, have been increasingly recognized among healthcare workers. However, this problem has neither been studied nor reported in Thailand. The objectives of this study are : to (a) delineate the prevalence of latex allergy among healthcare workers in Thailand ; (b) determine the risk factors for the development of latex allergy among hospital personnel in Thailand ;(c) study clinical presentation of latex allergy among those with and without positive latex skin testing ; and (d) undertake a preliminary electrophoretic pattern study of latex proteins contained in latex extracts made from latex gloves commonly used in Siriraj Hospital. The method included a questionnaire survey which was completed by 405 health personnel. The questionnaire pertained to allergy history to latex products. Skin-prick testing, using latex glove extracts, was performed in 227 subjects. Sodium dodecyl sulphate polyacryamide gel electrophoresis (SDS-PAGE) was performed with protein extract preparations from latex gloves. The results showed that 50 subjects reported experiences of one or more latex-related allergic symptoms amounting to a prevalence of 12.4 percent (95 per cent confidence interval {CI}, 9.2 to 15.6). Seven of 227 participants (3.16 per cent) had positive skin-prick tests to latex. The following risk factors were significantly associated with latex allergy : age more than 35 years old (odds ratio {OR} = 2.58; 95 per cent CI = 1.35- 4.93), having a history of prior atopic diseases (OR = 2.06; 95 per cent CI = 1.08-3.93), and having worked with latex gloves for more than 10 years (OR = 2.00; 95 per cent CI = 1.05 –3.82). The most commonly reported symptoms of latex allergy were skin reactions (98 percent). Other symptoms such as rhinitis, conjunctivitis, asthma and anaphylaxis were encountered with lower frequencies. A preliminary study of the electrophoretic pattern of latex glove extracts revealed distinguishable protein bands at 14 kd, 20 kd and 30-43 kd. In conclusion, latex allergic symptoms are common complaints among healthcare personnel in Thailand. Severe symptoms, including anaphylaxis, were noted in one patient. Potential risk factors identified are age more than 35 years old, history of prior atopic diseases, and long contact duration with latex gloves. Measures to cope with such problems will need to be designed for such individuals in the future.enEpidemiologyLatex allergyHealthcare personnelArticle