Dhavare, B SNandal, N VBalsara, J JChandorkar, A G1983-01-012009-06-011983-01-012009-06-011983-01-01Dhavare BS, Nandal NV, Balsara JJ, Chandorkar AG. Effect of drugs influencing central 5-hydroxytryptamine mechanisms on amantadine-induced stereotyped behaviour in the rat. Indian Journal of Physiology and Pharmacology. 1983 Jan-Mar; 27(1): 19-24http://imsear.searo.who.int/handle/123456789/108667Pretreatment with L-tryptophan, a precursor of 5-HT, was found to decrease the intensity of stereotyped behaviour induced by amantadine, while methysergide, a 5-HT antagonist, was found to increase the intensity of amantadine-induced stereotypy. These results suggest that the intensity of amantadine-induced stereotypy depends on the balance between central dopamine and 5-HT systems and that the central 5-HT systems may have an opposing, tonic effect upon central dopamine systems involved in the mediation of stereotypy. In contrast to L-tryptophan, however, pretreatment with quipazine, a 5-HT agonist, and clomipramine, a selective 5-HT neuronal reuptake blocker, was found to potentiate the stereotyped behaviour induced by amantadine.engAmantadine --pharmacologyAnimalsClomipramine --pharmacologyHumansMaleMethysergide --pharmacologyQuipazine --pharmacologyRatsSerotonin --physiologyStereotyped Behavior --drug effectsTryptophan --pharmacologyJournal Article