Sundar, J SuvarnaVarma, K MadhuSatish, R KalyanSajjan, Girija STanikonda, Rambabu2015-07-102015-07-102015-04Sundar J Suvarna, Varma K Madhu, Satish R Kalyan, Sajjan Girija S, Tanikonda Rambabu. A Biological Approach in Repair of Damaged Dental Pulp and Periapical Tissues using Platelet Rich Fibrin, Mineral Trioxide Aggregate and Laser Biostimulation. IJSS Case Reports & Reviews. 2015 Apr; 1(11): 44-50.http://imsear.searo.who.int/handle/123456789/159474This article describes about a biological approach in the repair of dental pulp and periapical tissues using biomaterials (platelet rich fibrin [PRF] and mineral trioxide aggregate [MTA]) and laser biostimulation. Case 1: Pulpotomy with PRF, MTA, and laser biostimulation. Patient follow-up was done at 1, 3, and 6 months. On 6 months follow-up, the patient was asymptomatic and tooth responded positively to pulp tests. Radiograph revealed normal periodontal ligament space and trabecular bone pattern. Case 2: Apexification procedure using PRF, MTA, and laser biostimulation in 31 and 41. Patient follow-up was done at 1, 3, and 6 months. On 6 months follow-up, radiograph revealed relative root lengthening, thickening of the canal walls in the apical one-third of root, and a healing lesion. Repair and regenerative potential of PRF, an enhanced cellular metabolism with laser biostimulation in combination with the sealing ability of MTA enhances the clinical success outcomes in pulpotomy and apexification procedures.enApexificationBiocompatible materialsLow-level laser biostimulationPulpotomyAdolescentApexification --methodsBiocompatible Materials --administration & dosageBiocompatible Materials --therapeutic useDental Pulp --injuriesDental Pulp --therapyFemaleHumansLaser Therapy, Low-Level --methodsLaser Therapy, Low-Level --therapeutic useMalePeriapical Tissue --injuriesPeriapical Tissue --therapyPulpotomy --methodsPulpotomy --therapeutic useYoung AdultArticle