AimenGul, MHSohail, RPahwani, RSiddiqui, ARNadeem, SWardak, ABNazir, HAhmad, SAhmed, A.2025-05-122025-05-122024-09Aimen, Gul MH, Sohail R, Pahwani R, Siddiqui AR, Nadeem S, Wardak AB, Nazir H, Ahmad S, Ahmed A.. Investigating the therapeutic potential of venom-derived compounds for the management of Alzheimer's disease: a comprehensive review . International Journal of Scientific Reports. 2024 Sep; 10(9): 340-3452454-21562454-2164https://imsear.searo.who.int/handle/123456789/246989Alzheimer’s disease is a comprehensive clinical syndrome featuring cognitive, emotional, and volitional function deterioration. Treatment strategies for Alzheimer's disease involve a mix of pharmacological and non-pharmacological approaches. Current treatments focus on palliative care with limited impact on the disease course. Venom-derived substances, known for their neuroactive properties, have emerged as a novel approach to Alzheimer's treatment. Our team conducted a thorough search for electronic literature related to therapeutic venom-derived substances efficacy in Alzheimer’s disease in different databases, including Medline, PubMed, Google Scholar, and Psych INFO, up to May 2024. In this article, the therapeutic effects of various venom-derived substances effects in Alzheimer’s disease are discussed. Various substances grant anti-inflammatory and anti-oxidant effects. The clinical application of venom-derived therapy is still a long way ahead, still, researchers believe that the ongoing work will eventually allow its compounds to be considered definitive candidates in various therapies in upcoming years.Alzheimer’s diseasePharmacological treatmentBee venomsVenom-derived substancesTherapeutic effectsJournal ArticleIndiaDepartment of Medicine, BahawalVictoria Hospital, PakistanDepartment of Medicine, Lady Reading Hospital, Peshawar, PakistanDepartment of Medicine, Quaid-Azam Medical College Bahawalpur, PakistanDepartment of Medicine, Jinnah Sindh Medical University Karachi, PakistanDepartment of Medicine, Liaquat University of Medical and Health Sciences,Jamshoro, Sindh, PakistanDepartment of Medicine, Multan Institute of Cardiology, PakistanDepartment of Medicine, Razia Bahlol Hospital, AfghanistanDepartment of Medicine, Hayatabad Medical Complex, PakistanDepartment of Medicine, Khyber Medical College, Peshawar, PakistanDepartment of Medicine, Cork University Hospital, Cork, Ireland