Krishnamurthy, SriramSeth, AnjuPuri, ArchanaAnand, RamaAneja, Satinder2012-10-302012-10-302010-06Krishnamurthy Sriram, Seth Anju, Puri Archana, Anand Rama, Aneja Satinder. Ovarian tumors with elevated ca-125 levels and severe juvenile hypothyroidism: A need for increased awareness. Indian Journal of Pediatrics. 2010 June; 77(6): 693-694.http://imsear.searo.who.int/handle/123456789/142611A 15-yr-old girl presented with bilateral gross ovarian tumors, clinical features of long-standing unrecognized hypothyroidism and markedly elevated CA-125 levels. Ovarian resection was avoided, as the presentation was consistent with the Van Wyk and Grumbach syndrome; and the patient was treated with replacement of thyroid hormone. Regression of the ovarian tumors occurred 6 months after initiation of the treatment. The authors emphasise the need for increased awareness and screening for hypothyroidism in patients with ovarian tumors, in order to prevent inadvertent operative interventions.enOvarian tumorsHypothyroidismThyroid hormoneAdolescentCA-125 Antigen --bloodFemaleHumansHypothyroidism --drug therapyHypothyroidism --pathologyOvarian Cysts --drug therapyOvarian Cysts --pathologyOvarian Neoplasms --drug therapyOvarian Neoplasms --pathologySyndromeThyroid Hormones --therapeutic useThyroxine --therapeutic useTreatment OutcomeTumor Markers, Biological --bloodArticle