Khokhani, R CChopra, PKarnik, N DBajan, K DAiliani, RWaknis, S SJoseph, T AChawla, K P1993-10-012009-05-301993-10-012009-05-301993-10-01Khokhani RC, Chopra P, Karnik ND, Bajan KD, Ailiani R, Waknis SS, Joseph TA, Chawla KP. Amlodipine in mild and moderate hypertension: initial Indian experience. Journal of the Association of Physicians of India. 1993 Oct; 41(10): 662-3http://imsear.searo.who.int/handle/123456789/90502In an open, non-comparative, variable-dose study, 20 outpatients with mild to moderate essential hypertension were treated with 5-10 mg amlodipine once daily for 4 weeks, after their blood pressures had stabilized on placebo. Amlodipine produced a significant decrease in blood pressure (P < 0.05) from the initial mean of 162/100 mm Hg to 139/85 mm Hg at 4 weeks. 80% of the patients reached the goal diastolic blood pressure of < or = 90 mm Hg with a once-daily dose of 5 mg amlodipine within 2 weeks. The remaining 20% also attained the goal diastolic blood pressure within 4 weeks, with a one-step increase in the dose to 10 mg at 2 weeks. Amlodipine maintained blood pressure reduction throughout the 24-hours dosing interval with a once-daily dose. Notably, no side effects were observed; pulse rate, electrocardiogram, and laboratory parameters were not significantly altered with therapy. Amlodipine in a single daily dose of 5-10 mg is effective and well tolerated in the treatment of patients with mild to moderate hypertension.engAdultAgedAmlodipine --therapeutic useBlood Pressure --drug effectsFemaleHumansHypertension --drug therapyMaleMiddle AgedSingle-Blind MethodClinical Trial