Verma, A.Choudhuri, S. R.Choudhuri, K. R.BS, R. P.Chakraborty, A.Parihar, S.2023-08-192023-08-192022-06Verma A., Choudhuri S. R., Choudhuri K. R., BS R. P., Chakraborty A., Parihar S.. Phenytoin Induced Gingival Enlargement. Indian Journal of Preventive and Social Medicine. 2022 Jun; 53(2): 149-1540301-1216http://imsear.searo.who.int/handle/123456789/224006Certain anticonvulsants, cyclosporine, and calcium channel blockers like amlodipine have been shown to produce clinically and histologically similar gingival enlargements in certain susceptible patients in response to local factors. These drugs appear to be similar with respect to their pharmacologic mechanism of action at the cellular level. Therefore, it is tempting to speculate that these agents may act similarly on gingival connective tissue and cause a hyperplastic response. This tissue reaction may involve a disturbance of calcium ion influx into specific cell populations with a resulting alteration in collagen metabolism and other host cell response mechanisms. A connection between ion exchange, folate uptake, collagenase activation, and bacterial inflammation may exist. The management involves Phase I therapy followed by surgical intervention. The purpose of these case reports is to highlight certain modifications in existing surgical techniques like gingivectomy, to have better aesthetic and functional outcome.PhenytoinGingivectomyGingival HyperplasiaAnticonvulsantsRoot Planning.Journal ArticleIndiaPost Graduate Student, Department of Periodontics, Gurunanak Institute of Dental Sciences & Research, Email: drapoorva19@gmail.com2.Reader, Department of Periodontics, Gurunanak Institute of Dental Sciences and Research; Email: roychaudhurisoumya1048@gmail.com3.Senior Lecturer, Department of Periodontics, Gurunanak Institute of Dental Sciences and Research, Email:kaushikrc8@gmail.com4.Department of Periodontics, Gurunanak Institute of Dental Sciences and Research, Email: drraviprakashbs@yahoo.com5.Department of Periodontics, Gurunanak Institute of Dental Sciences and Research, Email:abhijitperiodontist@gmail.com6.Professor, Division of Periodontics, Faculty of Dental Sciences, Institute of Medical Sciences, BHU, Email: saritaparihar@bhu.ac.in