Ray, ANaik, S L DSharma, B K2002-10-102009-06-012002-10-102009-06-012002-10-10Ray A, Naik SL, Sharma BK. Distribution of prognostically unfavourable product of c-erbB-2 oncogene and EGF-R in carcinomas of the breast and uterine cervix. Indian Journal of Physiology and Pharmacology. 2002 Oct; 46(4): 423-33http://imsear.searo.who.int/handle/123456789/108582A comparative study was undertaken between cancer of the uterine cervix (n = 50) and female breast cancer (n = 50) with reference to the expression of c-erbB-2 oncoprotein (HER-2/neu) and that of epidermal growth factor receptor (EGF-R), both being highly homologous structurally. Expressions of EGF-R and c-erbB-2 oncoprotein were viewed in breast and cervical cancer tissues by immunochemical staining. Cervical cancer cases showed much higher expression of EGF-R which also revealed significant association with the expression of c-erbB-2 oncoprotein and tumour grading. Among breast cancer cases, over-expression of EGF-R correlated significantly with metastasis of lymph node; and expression of c-erbB-2 oncoprotein showed a significant relationship with histological grading of the tumour. Moreover, an association was noticed between the tumour grade and the concomitant immuno positive expression of EGF-R and c-erbB-2. Our study revealed an existence of a conflicting pattern in the expression of EGF-R and c-erbB-2 oncoprotein between carcinomas of the breast and uterine cervix.engAdultBreast Neoplasms --metabolismCarcinoma, Ductal, Breast --metabolismCarcinoma, Squamous Cell --metabolismFemaleGene Expression Regulation, Neoplastic --physiologyHumansMiddle AgedReceptor, Epidermal Growth Factor --metabolismReceptor, erbB-2 --geneticsUterine Neoplasms --metabolismComparative Study