Bharathi-Devi, SRCoral, KGayathree, KBharathselvi, MSivasankar, SBiswas, JRishi, PNatarajan, SBadrinath, SSAngayarkanni, N2020-04-102020-04-102019-10Bharathi-Devi SR, Coral K, Gayathree K, Bharathselvi M, Sivasankar S, Biswas J, Rishi P, Natarajan S, Badrinath SS, Angayarkanni N. Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies. Indian Journal of Ophthalmology. 2019 Oct; 67(10): 1762-17650301-47381998-3689http://imsear.searo.who.int/handle/123456789/197594We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.Adiponectin and paraoxonasediabetic retinopathyPEDFVEGFJournal ArticleIndiaRS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, IndiaDepartment of Uveitis, Medical Research Foundation, Chennai, IndiaShri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Chennai, IndiaAditya Jyot Eye Hospital, Mumbai, India